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Son mГ©canisme d'action exact est inconnu. Les mГ©dicaments opiacГ©s tels que la morphine peuvent avoir un effet additif. Le modafinil est un inhibiteur rГ©versible sГ©lectif et non direct de la recapture de la noradrГ©naline. Cette amГ©lioration peut se produire indГ©pendamment du fait que l'utilisateur soit obligГ© de rester Г©veillГ© ou qu'il s'autorise Г  faire une sieste. Le modafinil est un dГ©rivГ© de la benzazГ©pine substituГ©e, une classe de composГ©s chimiquement similaire aux amphГ©tamines, dans ce cas sa cible est le rГ©cepteur 5-HT2C, bien qu'il ne s'agisse pas d'une amphГ©tamine et qu'il ait un profil pharmacologique diffГ©rent. Les effets indГ©sirables les plus courants (moins de 3 %) sont les nausГ©es, les maux de tГЄte et la somnolence. Le modafinil est mГ©tabolisГ© Г  95 % par le foie. Les personnes qui ont dГ©jГ  pris de la propafГ©none pourraient avoir un risque accru d'effets secondaires. Modafinil a le nom commercial Provigil. Le modafinil agit en modulant la liaison du modafinil au transporteur de la sГ©rotonine (5-HTT). Au lieu de cela, cela permet au cerveau de recevoir plus de messages indiquant quand ГЄtre Г©veillГ© et quand dormir. canada modafinil Les effets secondaires courants comprennent les maux de tГЄte, les troubles du sommeil et les nausГ©es, qui peuvent ГЄtre attГ©nuГ©s par une prise le matin. Modafinil est le nom gГ©nГ©rique du composant actif du mГ©dicament sur ordonnance Modafinil. D'autres mГ©dicaments sont utilisГ©s avec le modafinil pour augmenter la vigilance, mais il y a un manque de preuves que le modafinil amГ©liore la cognition chez les individus en bonne santГ©. L'effet du modafinil sur le neurotransmetteur de la dopamine rend Г©galement plus difficile l'endormissement du corps. Des Г©vГ©nements cardiovasculaires dose-dГ©pendants, y compris l'hypertension, les arythmies cardiaques et l'angine de poitrine, ont Г©tГ© signalГ©s chez des personnes suivant un rГ©gime de modafinil Г  long terme. L'ingrГ©dient actif du modafinil, le monohydrate de modafinil, est un solide cristallin granuleux blanc Г  blanc cassГ© soluble dans l'Г©thanol et l'eau. Le modafinil est mГ©tabolisГ© par l'enzyme CYP2C19. Il est pris par voie orale, avec un certain nombre de comprimГ©s par jour. Dans la recherche, Modafinil a Г©galement Г©tГ© utilisГ© en combinaison avec de l'alcool et d'autres stimulants du SNC pour rГ©duire la quantitГ© d'alcool consommГ©e sans augmentation des nausГ©es ou de la gueule de bois. Le modafinil a une demi-vie de 7 Г  12 heures. Le modafinil est l'Г©nantiomГЁre S du dГ©rivГ© d'amphГ©tamine propionolol; en substance, un isomГЁre d'amphГ©tamine. En plus de stimuler le systГЁme nerveux central, le modafinil peut ГЄtre utile dans le traitement de l'apnГ©e du sommeil. 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