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Il a Г©tГ© largement utilisГ© dans la recherche sur la narcolepsie. La posologie variera d'un patient Г  l'autre. Le modafinil a une masse molГ©culaire de 318,9 g/mol et une constante de dissociation molГ©culaire (pKa) de 4,66. ГЂ l'Г©poque, on pensait que le composГ© Г©tait un agoniste des rГ©cepteurs de la dopamine, mais il s'est avГ©rГ© plus tard qu'il s'agissait d'un antagoniste des rГ©cepteurs de la dopamine non D1 et non D2. Le modafinil est un antagoniste de l'adГ©nosine qui agit en augmentant l'adГ©nosine extracellulaire, activant ainsi les rГ©cepteurs inhibiteurs de l'adГ©nosine A1. L'arrГЄt de l'utilisation de Modafinil entraГ®ne une diminution des taux sanguins de mГ©thylphГ©nidate. Par la suite, il a Г©tГ© approuvГ© pour des utilisations telles que le traitement de la narcolepsie, du dГ©calage horaire, des troubles du sommeil liГ©s au travail postГ© et de l'apnГ©e obstructive du sommeil. Dans une Г©tude sur des enfants somnolents atteints de TDAH, il n'y avait aucune diffГ©rence entre les effets du modafinil et du diazГ©pam. Le modafinil peut ГЄtre disponible en version sur ordonnance ou en vente libre, selon la juridiction. Le modafinil figure sur la liste des mГ©dicaments essentiels de l'Organisation mondiale de la santГ©, les mГ©dicaments les plus sГ»rs et les plus efficaces nГ©cessaires dans un systГЁme de santГ©. Le modafinil est un stimulant du systГЁme nerveux central (SNC) et agit principalement en se liant aux protГ©ines de transport des catГ©cholamines du cerveau pour augmenter les concentrations de ces neurotransmetteurs, notamment la noradrГ©naline et la dopamine. Le modafinil a Г©tГ© approuvГ© en tant que substance contrГґlГ©e de l'annexe IV par la Drug Enforcement Administration des Г‰tats-Unis en 1999, le plaГ§ant parmi les moins restrictives de toutes les substances. modafinil sans ordonnance Modafinil a le nom commercial Provigil et est disponible sous forme de comprimГ©s (100 mg, 200 mg, 400 mg et 600 mg). Sous son nom de marque, Modafinil est un stimulant du systГЁme nerveux central (SNC). Le modafinil ne produit pas le mГЄme degrГ© de vigilance que la cafГ©ine. Le composant actif du modafinil est connu sous le nom de R-(+)-modafinil. Le modafinil est la dГ©nomination commune internationale du mГ©dicament stimulant modafinil ou Provigil. Le manque de clartГ© est dГ» Г  plusieurs raisons, dont l'une est que toutes les Г©tudes souffraient de niveaux Г©levГ©s de dГ©fauts mГ©thodologiques. Il est rapidement et largement mГ©tabolisГ© dans le foie en mГ©tabolites pharmacologiquement inactifs. MГ©canisme d'action : Un analogue de la dopamine non stimulant qui agit sur le systГЁme noradrГ©nergique du SNC. Il a Г©tГ© utilisГ© comme agent de coupe et est donc souvent abusГ©. Le modafinil est Г©galement utilisГ© hors AMM comme prГ©tendu activateur cognitif pour amГ©liorer l'Г©veil dans les Г©tudes animales et humaines. Il n'est pas efficace pour les personnes souffrant de lГ©sions cГ©rГ©brales traumatiques. C'est le cas dans tous les autres pays de l'UE, au Royaume-Uni et aux Г‰tats-Unis. L'Г©tude a Г©tГ© dirigГ©e par Sebastian Sieben de l'UniversitГ© de Zurich et Larissa Simon de l'UniversitГ© de Pennsylvanie. Il est dГ©rivГ© du parfum de l'arbre psilocybine d'AmГ©rique du Sud. 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