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[Le Modafinil]

Cependant, il n'est pas recommandé par la FDA pour une utilisation comme activateur cognitif. Il a été largement utilisé dans la recherche sur la narcolepsie. La posologie variera d'un patient à l'autre. Le modafinil a une masse moléculaire de 318,9 g/mol et une constante de dissociation moléculaire (pKa) de 4,66. À l'époque, on pensait que le composé était un agoniste des récepteurs de la dopamine, mais il s'est avéré plus tard qu'il s'agissait d'un antagoniste des récepteurs de la dopamine non D1 et non D2. Le modafinil est un antagoniste de l'adénosine qui agit en augmentant l'adénosine extracellulaire, activant ainsi les récepteurs inhibiteurs de l'adénosine A1. L'arrêt de l'utilisation de Modafinil entraîne une diminution des taux sanguins de méthylphénidate. Par la suite, il a été approuvé pour des utilisations telles que le traitement de la narcolepsie, du décalage horaire, des troubles du sommeil liés au travail posté et de l'apnée obstructive du sommeil. Dans une étude sur des enfants somnolents atteints de TDAH, il n'y avait aucune différence entre les effets du modafinil et du diazépam. Le modafinil peut être disponible en version sur ordonnance ou en vente libre, selon la juridiction. Le modafinil figure sur la liste des médicaments essentiels de l'Organisation mondiale de la santé, les médicaments les plus sûrs et les plus efficaces nécessaires dans un système de santé. Le modafinil est un stimulant du système nerveux central (SNC) et agit principalement en se liant aux protéines de transport des catécholamines du cerveau pour augmenter les concentrations de ces neurotransmetteurs, notamment la noradrénaline et la dopamine. Le modafinil a été approuvé en tant que substance contrôlée de l'annexe IV par la Drug Enforcement Administration des États-Unis en 1999, le plaçant parmi les moins restrictives de toutes les substances. modafinil sans ordonnance Modafinil a le nom commercial Provigil et est disponible sous forme de comprimés (100 mg, 200 mg, 400 mg et 600 mg). Sous son nom de marque, Modafinil est un stimulant du système nerveux central (SNC). Le modafinil ne produit pas le même degré de vigilance que la caféine. Le composant actif du modafinil est connu sous le nom de R-(+)-modafinil. Le modafinil est la dénomination commune internationale du médicament stimulant modafinil ou Provigil. Le manque de clarté est dû à plusieurs raisons, dont l'une est que toutes les études souffraient de niveaux élevés de défauts méthodologiques. Il est rapidement et largement métabolisé dans le foie en métabolites pharmacologiquement inactifs. Mécanisme d'action : Un analogue de la dopamine non stimulant qui agit sur le système noradrénergique du SNC. Il a été utilisé comme agent de coupe et est donc souvent abusé. Le modafinil est également utilisé hors AMM comme prétendu activateur cognitif pour améliorer l'éveil dans les études animales et humaines. Il n'est pas efficace pour les personnes souffrant de lésions cérébrales traumatiques. C'est le cas dans tous les autres pays de l'UE, au Royaume-Uni et aux États-Unis. L'étude a été dirigée par Sebastian Sieben de l'Université de Zurich et Larissa Simon de l'Université de Pennsylvanie. Il est dérivé du parfum de l'arbre psilocybine d'Amérique du Sud. Son mode d'action précis n'est actuellement pas complètement compris.

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[wolfstaag]

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[Keganer]

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