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#11
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#12
Le modafinil, comme la plupart des inhibiteurs de la cholinestérase, est éliminé de l'organisme par l'action inhibitrice de la cholinestérase de l'acétylcholine, qui est libérée dans le cadre de l'action de l'influx nerveux. Les effets secondaires sont similaires à ceux des autres stimulants du système nerveux central. Le modafinil est rapidement absorbé lorsqu'il est pris par voie orale, avec des pics survenant entre une et deux heures. Le modafinil peut être classé comme un méthylphénidate, une amphétamine ou un autre médicament analogue. Le modafinil a été développé en France par les laboratoires Michel Jouvet et LaFont, qui ont été absorbés par Ciba-Geigy en 1994. Il a été utilisé pour traiter un certain nombre de troubles psychiatriques tels que la dépression, le trouble bipolaire et la schizophrénie. Lorsqu'il est dans le corps humain, le modafinil a la capacité d'affecter les voies neuronales du cerveau. Les effets secondaires graves du modafinil, bien que peu fréquents, peuvent inclure l'anaphylaxie, le syndrome de Stevens-Johnson, des hallucinations ou d'autres réactions psychotiques. Dans la narcolepsie, le cervelet, une partie du cerveau qui contrôle la coordination et les mouvements musculaires, est en sommeil pendant le sommeil. Le modafinil a une plus grande affinité pour le récepteur D2 que pour le récepteur D1. modafinil france acheter Le modafinil a une biodisponibilité moyenne de 80 % chez l'adulte et de 60 % chez l'enfant. Cela peut également améliorer la mémoire de travail. C'est un médicament non stimulant, ce qui signifie qu'il ne provoque pas d'augmentation de la fréquence cardiaque et de l'énergie chez les personnes sans antécédents d'abus de stimulants. Aux États-Unis, le modafinil peut être acheté sous forme de comprimés, de comprimés à libération prolongée et de gélules. Un autre essai contrôlé chez 12 volontaires sains a révélé que 200 mg étaient tout aussi efficaces. Rares réactions dermatologiques graves, y compris des réactions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antécédents de psychose. On ne sait toujours pas si le modafinil a un effet sur les récepteurs alpha2, gamma-aminobutyrique de type A ou N-méthyl-D-aspartate. Développé par la société pharmaceutique française Groupe Lafon, le modafinil est un stimulant, principalement utilisé pour aider les personnes très fatiguées à rester éveillées. Les effets de la drogue peuvent durer jusqu'à 12 heures au total, pendant lesquelles l'utilisateur ne doit pas conduire, utiliser de machinerie lourde ou s'engager dans une activité physiquement exigeante. Contrairement à l'étude de Wake Forest, les travaux de Sieben et Simon ont révélé une amélioration globale des performances cognitives et ont également identifié comment cela changeait en fonction des différences individuelles entre les participants à l'étude. Il est également disponible en tant que médicament générique. Une poignée de personnes atteintes de narcolepsie utilisent le modafinil comme option de traitement. La dopamine et la noradrénaline sont des composés chimiques apparentés qui se trouvent dans et influencent la fonction du système nerveux central.

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#13
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#14
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