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#2
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#3
Le modafinil peut être utilisé seul ou avec des psychostimulants tels que le méthylphénidate, l'amphétamine et la cocaïne. Le modafinil agit en modulant les niveaux de dopamine des neurotransmetteurs dans le cerveau. Le modafinil agit sur la dopamine, un neurotransmetteur d'acides aminés. La posologie recommandée de modafinil est de 100 à 200 mg par jour (un à deux comprimés de 100 mg le matin et un à deux comprimés de 100 mg le soir). Le modafinil n'est pas recommandé chez les patients atteints de maladie coronarienne, du phénomène de Raynaud ou ayant des antécédents d'arythmie cardiaque. Une dose de 200 milligrammes est prise par voie orale 2 à 4 fois par jour. Le modafinil était autrefois décrit comme un "agent nouveau, sûr et efficace pour éliminer la somnolence chez les travailleurs postés et les travailleurs de nuit". On pense que le modafinil a des effets favorisant l'éveil par les mécanismes suivants : Le modafinil est un médicament délivré sur ordonnance (autorisé au Royaume-Uni) développé dans les années 1970 par la société pharmaceutique française Academia et les laboratoires Lafon, pour le traitement de la narcolepsie et de l'insomnie du travail posté. Lorsqu'elles sont emmenées au travail, certaines personnes sont plus productives et ont moins de difficulté à se concentrer. Le modafinil est fabriqué à partir d'alkylacétoacétates aliphatiques, des esters de la classe générique des acides gras. Acheter Modafinil Ces substances agissent sur le cerveau pour vous aider à rester éveillé. Ils sont responsables des humeurs ressenties, ainsi que du besoin de sommeil et d'éveil, de la faim et de la libido. Le modafinil se prend par voie orale. Le médicament est disponible uniquement sur ordonnance au Royaume-Uni et sur ordonnance hors AMM aux États-Unis. Elle peut survenir jusqu'à plusieurs semaines après la première dose. Le modafinil est arrivé sur le marché comme traitement de la narcolepsie, et a ensuite été prescrit pour le traitement d'autres indications telles que la fatigue liée au travail posté et l'apnée obstructive du sommeil. La dopamine est associée à la régulation du sommeil, et une revue de 2010 a trouvé un lien entre le médicament et la libération de catécholamines dans le cerveau. Il est couramment utilisé dans l'Union européenne pour lutter contre la somnolence excessive causée par le travail posté ou comme traitement d'appoint pour les personnes souffrant d'apnée obstructive du sommeil. Le modafinil agit en augmentant les niveaux de neurotransmetteurs dans le cerveau, en particulier le neurotransmetteur dopamine. C'est un stimulant du système nerveux central qui agit en stimulant une substance chimique du cerveau appelée adénosine, responsable de la somnolence. La dose initiale habituelle est de 200 mg à prendre le matin et, si nécessaire, augmentée à 400 mg le soir. Le modafinil est commercialisé dans de nombreux pays et est disponible sur ordonnance aux États-Unis. En raison de ses propriétés stimulantes, le modafinil provoque une augmentation de la pression artérielle, de la fréquence cardiaque et de la glycémie. Cependant, lorsque les chercheurs ont analysé les données de sommeil sur la polysomnographie, la différence entre les groupes n'était pas significative. Aux États-Unis, le modafinil est approuvé pour une utilisation chez les adultes souffrant de somnolence causée par la narcolepsie.

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#4
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#9
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