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En tant que stimulant, le modafinil peut être utilisé pour améliorer les performances à court terme des personnes souffrant de privation de sommeil, de travail posté et de narcolepsie. Dans deux études, l'imagerie par résonance magnétique fonctionnelle (IRMf) a révélé les zones cérébrales affectées par le modafinil, montrant qu'il augmentait la dopamine dans ces zones. Le nom de marque le plus courant pour Modafinil est Provigil. Il a été développé par le neuroscientifique français Michel Jouvet et les laboratoires Lafon. Lorsque le cerveau et le corps reçoivent un neurotransmetteur, ils « s'installent » à cette concentration. Les médicaments sont souvent utilisés comme traitement d'appoint ou d'appoint pour les patients qui tentent d'améliorer leur vigilance diurne. Étant donné que la prévalence de la mutation CYP2C19 est élevée dans les populations caucasiennes, la biodisponibilité du modafinil est affectée. Des études chez le rat montrent que les niveaux de norépinéphrine dans le cerveau culminent dans les 5 à 15 minutes suivant l'administration de modafinil et que les niveaux de dopamine augmentent dans les 30 minutes. Il montre une relation dose-réponse, améliorant l'éveil, les performances énergétiques et cognitives, et la vigilance avec des doses croissantes. Il a été démontré que le modafinil améliore l'éveil et entraîne une augmentation des niveaux d'énergie. Le modafinil peut provoquer un rebond de la vigilance chez les personnes qui ont bu ou pris d'autres stimulants du SNC tels que la caféine. Le modafinil est parfois classé comme un agent favorisant l'éveil. Acheter Modafinil En Suisse Les autres produits du métabolisme sont excrétés sous forme inchangée dans les urines. On ne sait pas exactement comment Modafinil fonctionne. Les personnes qui prennent des médicaments appelés antidépresseurs peuvent également être blessées. Cela peut également réduire la libido des utilisateurs. De plus, le modafinil peut provoquer des réactions allergiques graves telles que l'anaphylaxie et le syndrome de Stevens-Johnson, qui surviennent généralement chez les personnes sensibles et sont généralement bénignes. Le modafinil s'est avéré avoir un potentiel modéré d'abus. Il est pris environ 30 minutes à 1 heure avant de se retirer. L'effet secondaire le plus courant peut inclure des troubles du sommeil. Il ne produit aucune stimulation subjective et aucun effet d'euphorie ou de gueule de bois. Le modafinil n'a pas d'indication approuvée pour les médecins travaillant par quarts aux États-Unis et n'a pas été approuvé par la Food and Drug Administration pour le travail par quarts. Le modafinil traverse également la barrière hémato-encéphalique. D'autres qui l'utilisent incluent des personnes qui traversent une période stressante de leur vie, comme un divorce, prennent une décision importante comme retourner à l'école, étudier pour un test ou un examen important, acheter une nouvelle maison ou même trouver un nouvel emploi.

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